魔芋葡甘聚糖药物载体的结构与性能

黄荣勋; 庞杰

doi:10.19303/j.issn.1008-0384.2017.03.011

魔芋葡甘聚糖药物载体的结构与性能

doi: 10.19303/j.issn.1008-0384.2017.03.011

黄荣勋,
庞杰^,

福建农林大学食品科学学院, 福建福州 350002

基金项目:

国家自然科学基金 31471704

国家自然科学基金 31271837

详细信息

作者简介:
黄荣勋 (1990-), 男, 硕士研究生, 研究方向:天然产物的开发与利用 (E-mail:562327802@qq.com)

通讯作者:
庞杰 (1965-), 男, 研究员, 博士生导师, 研究方向:多糖结构与功能活性的相关性、食品安全、食品文化 (E-mail:pang3721941@163.com)

中图分类号: O647.32
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- 被引次数: 0
出版历程
- 收稿日期: 2016-10-12
- 修回日期: 2017-01-14
- 刊出日期: 2017-03-28

The Structure and Properties of Konjac Glucomannan Drug Carrier

HUANG Rong-xun,
PANG Jie^,

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China

摘要

摘要: 为了分析魔芋葡甘聚糖（KGM）作为药物载体材料的结构特征及性能关系，通过复配方法制成KGM/CMC-Na、KGM/SAA、KGM/CMC-Na/SAA药物载体，进行孔隙率、电镜表征等方面的分析，并采用红外光谱分析其稳定性。试验结果：KGM/SAA、KGM/CMC-Na的复配能够起到协同增效的作用；KGM/SAA比KGM/CMC-Na、KGM/SAA/CMC-Na更为稳定；KGM/SAA药物载体的孔隙率较高，为73.00%；KGM/SAA药物载体的粒径大约为0.31~0.38mm，大小分布较为均匀。结果表明KGM/CMC-Na、KGM/SAA、KGM/CMC-Na/SAA中KGM/SAA最适宜作为药物载体。
- 魔芋葡甘聚糖 /
- 黏度 /
- 红外光谱 /
- 扫描电镜
Abstract: To analyze the structural characteristics and properties of Konjac Glucomannan (KGM) as drug carrier. Methods KGM/CMC-Na, KGM/SAA and KGM/CMC-Na/SAA drug carriers were prepared by complex method, and were analyzed with the porosity and electron microscopy. Infrared spectroscopy was used to analyze its stability. Results The combination of KGM/SAA and KGM/CMC-Na can play a synergistic effect; KGM/SAA is more stable than KGM/CMC-Na and KGM/SAA/CMC-Na; KGM/SAA is higher porosity, and its drug capacities is 73%; the particle size of KGM/SAA drug carrier is about 0.31~0.38mm, and uniform distribution. Conclusion KGM/SAA is the most suitable as drug carriers in three samples.
- Konjac Glucomannan /
- Viscosity /
- Infrared Spectrum /
- Scanning Electron Microscope

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图 1 3种复配物黏度的测定

Figure 1. Determination of viscosity of three kinds of compound

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图 2 以透射法方式测定的红外光谱

Figure 2. Infrared spectra measured by transmission method

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图 3 以反射法方式测定的红外光谱

Figure 3. Infrared spectra measured by reflection method

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图 4 冷冻干燥前后100颗药物载体的质量

Figure 4. The quality of 100 drug carriers before and after freeze drying

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图 5 复配物所制得的药物载体

注：A为KGM/SAA药物载体；B为KGM/SAA/CMC-Na药物载体。图 6同。

Figure 5. Drug carrier prepared by compound

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图 6 电镜下复配物所制得的药物载体

Figure 6. Electron microscope of the drug carrier prepared by the compound

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