植物病原真菌CFEM蛋白研究进展

付秀霞; 李志宇; 吴羽佳; 李魏

doi:10.19303/j.issn.1008-0384.2022.012.015

植物病原真菌CFEM蛋白研究进展

doi: 10.19303/j.issn.1008-0384.2022.012.015

1.
湖南农业大学植物保护学院，湖南　长沙　410128
2.
湖南省临湘市云湖街道农业综合服务中心，湖南　临湘　414300

基金项目: 杂交水稻国家重点实验室开放课题（2021KF05）；湖南省“揭榜挂帅”项目（2021NK1040）；湖南省自然科学基金项目（2021JJ30010）；湖南省研究生科研创新项目（2022XC066）

详细信息

作者简介:
付秀霞（1998−），女，硕士，研究方向：植物与病原物互作（E-mail：1943736689@qq.com）

通讯作者:
李魏（1983−），男，博士，教授，研究方向：植物与病原物互作（E-mail：liwei350551@163.com）

中图分类号: S 435
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出版历程
- 收稿日期: 2022-10-12
- 录用日期: 2022-10-12
- 修回日期: 2022-10-21
- 网络出版日期: 2022-12-28
- 刊出日期: 2022-03-28

Research Progress on CFEM Proteins in Phytopathogenic Fungi

FU Xiuxia^1
,,
LI Zhiyu²,
WU Yujia¹,
LI Wei^{1
, ,}

1.
College of Plant Protection, Hunan Agricultural University, Changsha, Hunan　410128, China
2.
Comprehensive Agricultural Service Center in Yunhu Street, Linxiang, Hunan　414300, China

摘要

摘要: 病原真菌在侵染植物过程中，往往分泌效应因子增加致病性或被寄主抗病基因识别激发寄主强烈抗性，因此效应因子在植物-病原物的互作中发挥重要作用。CFEM（Common in Fungal Extracellular Membrane）蛋白是真菌中特有的一类位于细胞外膜的蛋白，往往起效应因子的作用。本文综述了植物病原真菌CFEM蛋白家族的结构特点，在不同物种中的表达和定位，CFEM蛋白对真菌胞内铁吸收和生长发育方面的调控作用，抑制寄主免疫反应和促进真菌寄生的作用机制以及CFEM蛋白起源和进化过程等方面的研究进展，同时对目前CFEM蛋白研究有待阐明的问题进行了讨论并展望了未来的研究方向。本文将有助于人们进一步了解植物-病原真菌互作分子机理以及CFEM蛋白的致病机理，为培育作物抗病品种和制定植物真菌病害防控策略提供参考。
- 植物病原真菌 /
- CFEM蛋白 /
- 植物免疫 /
- 铁吸收
Abstract: In the process of infecting plants, pathogenic fungi may often secrete effectors to increase pathogenicity, or conversely, be recognized by the host to trigger resistance. Hence, such effectors are crucial for the well-being of a plant at time of a pathogenic intrusion. As an effector, CFEM (common in fungal extracellular membrane) protein is found only in the outer membrane of a fungal pathogen. This article reviews the origin, evolution, growth, development, structural characteristics, expressions and localization in different species, and intracellular iron absorption regulations of the CFEM protein family as well as the host immunology and infection-promoting factors associated with the proteins in the phytopathogens. Some of the yet-to-be-clarified issues on the molecular mechanisms and plant-pathogen interactions relating to CFEM proteins are discussed to facilitate the cultivation of disease-resistant plants and the development of ecologically friendly disease control strategies on crops.
- Phytopathogenic fungi /
- CFEM protein /
- plant immunity /
- iron absorption

HTML全文

图 1 CFEM结构域中高度保守的半胱氨酸

Figure 1. Highly conserved cysteines in CFEM protein domain

下载: 全尺寸图片幻灯片

图 2 白色念珠菌Csa2蛋白的CFEM结构

a：Csa2蛋白3个CFEM结构域的3D晶体结构为三聚体（引自NCBI）； b：Csa2蛋白的分子组分及它们之间相互作用示意图。A、B、C分别代表3个不同的CFEM结构域，1，2，3分别代表血红素B/C、氯离子和1,2-乙二醇。

Figure 2. Structure of CFEM protein domain in Csa2 of Candida albicans

a: “3D crystal structure of 3 CFEM protein domains in Csa2 is a trimer” as quoted from NCBI; b: Schematic molecular components and interactions of Csa2. A, B, and C represent 3 CFEM protein domains; 1, 2, and 3 represent heme B/C, chloride ion, and 1,2-ethanediol, respectively.

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