Effects of Liquid Culture for Monascus on Monacolin K and Lovastatin Production

HUANG Ying-ying; YANG Cheng-long; CHEN Yuan

doi:10.19303/j.issn.1008-0384.2013.08.018

Volume 28 Issue 8

Aug. 2013

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HUANG Ying-ying, YANG Cheng-long, CHEN Yuan. Effects of Liquid Culture for Monascus on Monacolin K and Lovastatin Production[J]. Fujian Journal of Agricultural Sciences, 2013, 28(8): 817-822. doi: 10.19303/j.issn.1008-0384.2013.08.018

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HUANG Ying-ying, YANG Cheng-long, CHEN Yuan. Effects of Liquid Culture for Monascus on Monacolin K and Lovastatin Production[J]. Fujian Journal of Agricultural Sciences, 2013, 28(8): 817-822. doi: 10.19303/j.issn.1008-0384.2013.08.018

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Effects of Liquid Culture for Monascus on Monacolin K and Lovastatin Production

doi: 10.19303/j.issn.1008-0384.2013.08.018

Institute of Agricultural Engineering Technology,Fujian Academy of Agricultural Sciences

Received Date: 2013-06-21
Publish Date: 2013-08-18

Abstract

Abstract

The effects of medium compositions and culture conditions in Monascus liquid culture were studied on the production and the ratio of Monacolin K and Lovastatin.The optimal temperature-shift cultivation was 2days culture at 30℃followed with 7days at 26℃to increase the production of acid form Monacolin K.By this culture conditions, the proportion of acid form Monacolin K in total Monascus products reached to 87% and it was 2.63times of the ratio produced with constant temperature cultivation at 26℃.Comparing with basic culture medium, additional 8% xylose, 3% peptone, 0.2% NaNO3, 0.2% KH2PO4and 0.35% MgSO4added into the basic medium was the optimal composition that produced the highest amount of Lovastatin compounds with the culture conditions in 6%inoculums size, 160rmin-1 rotate speed at the optimal temperature-shift cultivation.The ratio of acid form Monacolin K was 18times of it produced by the basic medium.
- Monascus spp.,
- Monacolin K,
- Lovastatin,
- proportion of acid form,
- liquid culture

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References(25)

References

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