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不同植物来源特种蜂蜜生物活性评价

韩凌云 张国志 刘瑶 李珊珊 胡福良

韩凌云,张国志,刘瑶,等. 不同植物来源特种蜂蜜生物活性评价 [J]. 福建农业学报,2024,39(7):857−867 doi: 10.19303/j.issn.1008-0384.2024.07.013
引用本文: 韩凌云,张国志,刘瑶,等. 不同植物来源特种蜂蜜生物活性评价 [J]. 福建农业学报,2024,39(7):857−867 doi: 10.19303/j.issn.1008-0384.2024.07.013
HAN L Y, ZHANG G Z, LIU Y, et al. Bioactivities of Honeys from Bees Fed on Different Plants [J]. Fujian Journal of Agricultural Sciences,2024,39(7):857−867 doi: 10.19303/j.issn.1008-0384.2024.07.013
Citation: HAN L Y, ZHANG G Z, LIU Y, et al. Bioactivities of Honeys from Bees Fed on Different Plants [J]. Fujian Journal of Agricultural Sciences,2024,39(7):857−867 doi: 10.19303/j.issn.1008-0384.2024.07.013

不同植物来源特种蜂蜜生物活性评价

doi: 10.19303/j.issn.1008-0384.2024.07.013
基金项目: 现代农业产业技术体系建设专项(CARS-44)
详细信息
    作者简介:

    韩凌云(1998 —),女,硕士研究生,主要从事蜂蜜生物活性及质量控制研究,E-mail:22117054@zju.edu.cn

    通讯作者:

    胡福良(1964 —),男,博士,教授,主要从事蜜蜂科学与蜂产品功能营养研究,E-mail:flhu@zju.edu.cn

  • 中图分类号: S896

Bioactivities of Honeys from Bees Fed on Different Plants

  • 摘要:   目的  特种蜂蜜具有较强的抗氧化能力和抗菌活性,并拥有来自于植物的药用特性,其开发利用具有巨大的潜力与价值。本研究旨在对中国境内的多种特种蜂蜜进行比对分析,以期找到具有优异生物活性的样本,为蜂蜜在医学和保健领域的应用提供科学依据。  方法  检测分析33种不同植物来源的特种蜂蜜的理化指标和生物活性,通过自由基清除法和总抗氧化能力检测法对蜂蜜抗氧化活性进行评价,并使用琼脂扩散法和微量肉汤稀释法检测样品的抗菌活性。  结果  所有蜂蜜样品的理化指标均符合国家标准规定;在33种蜂蜜中,米团蜜具有最强的抗氧化活性,板栗蜜、藿香蜜也表现良好。对金黄色葡萄球菌和大肠杆菌抗菌能力最强的分别为茴香蜜和枸杞蜜。此外,蜂蜜的抗氧化能力与总酚含量呈显著正相关,与抗菌能力的相关性不显著。  结论  米团、茴香、藿香蜂蜜等是具有优良生物活性的特种蜂蜜,它们具有进一步开发利用的潜力和价值。本研究结果可为当前蜂蜜消费市场等级评定提供依据。
  • 表  1  蜂蜜样品信息

    Table  1.   Information on honey samples

    样品名称
    Sample name
    植物来源
    Plant origin
    地理来源
    Geographical origin
    采样时间
    Sampling time
    板栗蜜 板栗 Castanea mollissima Blume 浙江 2022年
    柽柳蜜 柽柳 Tamarix chinensis Lour . 西藏 2020年
    鹅掌柴蜜 鹅掌柴 Schefflera octophylla (Linn.) Frodin 湖北 2021年
    枸杞蜜 枸杞 Lycium chinense Miller 西藏 2020年
    红柳蜜 多枝柽柳 Tamarix ramosissima Ledeb. 新疆 2018年
    黄芪蜜 黄芪 Astragalus membranaceus (Fisch.) Bunge 甘肃 2020年
    黄芩蜜 黄芩 Scutellaria baicalensis Georgi 甘肃 2020年
    茴香蜜 茴香 Foeniculum vulgare Mill. 甘肃 2020年
    火炭母蜜 火炭母 Persicaria chinensis (L.) H. Gross 重庆 2021年
    藿香蜜 藿香 Agastache rugosa (Fisch. & C. A. Mey.) Kuntze 重庆 2021年
    九龙藤蜜 龙须藤 Phanera championii Benth. 广西 2021年
    桔梗蜜 桔梗 Platycodon grandiflorus (Jacq.) A. DC. 安徽 2020年
    咖啡蜜 咖啡树 Coffea arabica 云南 2021年
    柯树蜜 柯树 Lithocarpus glaber (Thunb.) Nakai 浙江 2021年
    苦丁茶蜜 大叶冬青 Ilex latifolia Thunb. 浙江 2021年
    狼牙刺蜜 白刺花 Sophora davidii Kom. ex Pavol. 西藏 2021年
    罗布麻蜜 罗布麻 Apocynum venetum L. 新疆 2020年
    米团蜜 米团花 Leucosceptrum canum Sm. 云南 2021年
    木通蜜 木通 Akebia quinata (Houtt.) Decne. 重庆 2021年
    枇杷蜜 枇杷 Eriobotrya japonica (Thunb.) Lindl. 浙江 2021年
    苹果蜜 苹果 Malus pumila Mill. 甘肃 2020年
    蒲公英蜜 蒲公英 Taraxacum mongolicum Hand.-Mazz. 新疆 2019年
    沙枣蜜 沙枣 Elaeagnus angustifolia L. 新疆 2020年
    苕子蜜 苕子Vicia dasycarpa Ten. 云南 2021年
    石榴蜜 石榴 Punica granatum L. 安徽 2020年
    五倍子蜜 盐肤木 Rhus chinensis Mill. 重庆 2021年
    夏枯草蜜 夏枯草 Prunella vulgaris L. 河南 2019年
    玄参蜜 玄参 Scrophularia ningpoensis Hemsl. 重庆 2021年
    薰衣草蜜 薰衣草 Lavandula angustifolia Mill. 新疆 2020年
    野桂花蜜 野桂花 Osmanthus yunnanensis (Franch.) P. S. Green 江西 2021年
    野黄柏蜜 川黄檗 Phellodendron chinense Schneid. 重庆 2019年
    益母草蜜 益母草 Leonurus japonicus Houtt. 云南 2019年
    益智花蜜 益智 Alpinia oxyphylla Miq. 广东 2019年
    下载: 导出CSV

    表  2  不同特种蜂蜜样品理化参数

    Table  2.   Physicochemical parameters of honey

    样品
    Sample
    水分
    Hydration/%
    色度值
    Chrominance value/
    mm
    果葡比
    Fructoglucose
    ratio
    5-羟甲基糠醛
    5-hydroxymethylfurfural/
    (mg·kg−1)
    淀粉酶值
    Amylase value/
    (mL·g−1·h−1)
    电导率
    Conductivity/
    (μs·cm−1)
    板栗蜜 16.97±0.09 150.00±0.77 1.00±0.00 16.86±0.08 4.13±0.68 676.00±9.64
    柽柳蜜 20.95±0.18 38.00±0.00 1.15±0.02 0.63±0.03 40.00±2.01 647.30±5.42
    鹅掌柴蜜 20.63±0.10 23.00±0.00 1.02±0.00 0.33±0.03 10.00±0.79 207.60±4.17
    枸杞蜜 18.41±0.08 22.00±0.00 1.17±0.00 0.38±0.01 30.00±1.47 284.00±2.35
    红柳蜜 17.62±0.18 42.00±0.00 1.05±0.00 11.42±0.05 6.67±0.06 1067.00±5.50
    黄芪蜜 18.41±0.18 25.00±0.00 1.10±0.01 0.44±0.05 42.86±1.51 323.20±2.49
    黄芩蜜 19.19±0.03 22.00±0.00 1.13±0.00 0.51±0.03 33.33±1.17 278.10±0.77
    茴香蜜 19.11±0.08 88.00±0.00 1.57±0.00 0.94±0.03 50.00±2.01 587.30±0.35
    火炭母蜜 23.96±0.04 71.00±1.41 1.18±0.00 0.92±0.04 30.00±1.69 587.40±1.37
    藿香蜜 20.28±0.11 67.00±1.41 1.44±0.01 4.10±0.16 37.5±0.85 374.00±0.28
    九龙藤蜜 21.41±0.06 64.00±1.15 1.68±0.01 13.36±0.03 6.98±0.61 402.00±0.21
    桔梗蜜 23.89±0.28 31.00±0.00 1.14±0.04 1.51±0.03 17.65±1.36 336.10±4.11
    咖啡蜜 15.98±0.16 28.00±0.00 1.12±0.00 5.42±0.01 11.11±0.08 225.80±1.58
    柯树蜜 21.14±0.01 75.00±2.83 1.23±0.00 1.23±0.01 8.57±0.94 940.00±3.82
    苦丁茶蜜 19.11±0.08 83.00±1.41 1.58±0.01 8.71±0.03 6.32±0.22 758.80±3.28
    狼牙刺蜜 17.23±0.15 4.00±0.00 1.13±0.01 0.60±0.04 33.33±1.87 141.20±1.14
    罗布麻蜜 20.75±0.12 38.00±0.00 0.96±0.00 5.23±0.01 20.00±0.50 865.60±5.57
    米团蜜 19.15±0.00 150.00±2.08 1.27±0.02 2.68±0.02 16.60±2.16 1722.00±6.49
    木通蜜 19.34±0.31 32.00±0.00 1.00±0.01 0.34±0.03 9.52±1.40 219.00±1.38
    枇杷蜜 22.27±0.36 19.00±0.00 1.12±0.01 0.48±0.04 9.38±0.64 237.80±4.42
    苹果蜜 18.08±0.22 72.00±0.00 1.08±0.00 0.69±0.01 23.08±0.93 252.90±2.21
    蒲公英蜜 16.65±0.17 34.00±1.73 1.17±0.00 1.05±0.01 14.29±0.12 314.40±0.86
    沙枣蜜 21.06±0.09 37.00±0.00 1.04±0.00 2.03±0.03 25.00±1.32 320.30±2.71
    苕子蜜 19.34±0.28 11.00±0.00 1.10±0.01 2.80±0.05 23.00±2.19 179.40±0.42
    石榴蜜 22.04±0.04 20.00±0.00 1.24±0.00 0.40±0.01 30.00±1.34 245.40±3.49
    五倍子蜜 23.73±0.03 41.00±0.00 0.92±0.01 0.84±0.03 4.76±0.03 315.60±2.46
    夏枯草蜜 23.91±0.04 48.00±0.71 1.58±0.00 1.51±0.03 25.00±1.05 269.80±1.78
    玄参蜜 20.67±0.01 79.00±0.00 1.19±0.00 0.70±0.03 9.09±0.45 487.70±0.28
    薰衣草蜜 17.62±0.06 9.00±0.00 1.14±0.01 1.68±0.01 23.08±2.01 153.70±0.87
    野桂花蜜 21.41±0.18 31.00±0.00 1.13±0.00 0.53±0.03 8.57±0.11 302.80±0.42
    野黄柏蜜 19.97±0.07 30.00±0.00 0.99±0.00 2.39±0.02 4.23±0.48 299.40±3.16
    益母草蜜 17.55±0.11 75.00±2.65 1.10±0.00 1.26±0.03 60.00±2.31 826.10±4.64
    益智花蜜 19.11±0.05 70.00±0.71 1.10±0.01 6.18±0.02 8.57±1.04 503.20±2.21
    下载: 导出CSV

    表  3  蜂蜜样品的抗氧化活性

    Table  3.   Antioxidative activities of honeys

    样品名称
    Sample name
    总酚含量
    Total phenolic content/
    (µg·g−1)
    总抗氧化能力(FRAP法)
    Total antioxidant capacity/
    (mmol·g−1)
    DPPH自由基清除能力
    DPPH radical scavenging capacity/
    (mmol·kg−1)
    板栗蜜 1050.16±213.67ab 7.53±1.42a 2.73±0.95b
    柽柳蜜 357.84±131.10fghi 1.69±0.66a 0.67±0.05ef
    鹅掌柴蜜 323.94±25.32hi 7.65±0.42fg 0.26±0.04ef
    枸杞蜜 183.16±8.23fghi 0.94±0.33cdefg 0.27±0.04def
    红柳蜜 315.08±47.77fghi 1.65±0.30cdefg 1.61±0.15c
    黄芪蜜 287.13±78.18ghi 1.18±0.35efg 0.30±0.02ef
    黄芩蜜 275.58±91.77ghi 0.88±0.32fg 0.27±0.02ef
    茴香蜜 982.35±231.54bc 3.03±0.68cde 1.08±0.06cd
    火炭母蜜 327.85±62.54fghi 1.47±0.26defg 0.53±0.08def
    藿香蜜 676.83±170.85cde 3.37±0.91bcd 0.69±0.33def
    九龙藤蜜 406.29±18.48efghi 1.98±0.71cdefg 0.69±0.06def
    桔梗蜜 353.32±34.21fghi 0.94±0.32fg 0.28±0.02ef
    咖啡蜜 722.86±134.11cd 0.83±0.21fg 0.33±0.05ef
    柯树蜜 413.71±24.46efghi 2.27±0.72cdefg 0.70±0.04def
    苦丁茶蜜 616.91±22.68def 2.35±0.17cdefg 0.86±0.04de
    狼牙刺蜜 125.07±11.39i 0.69±0.38fg 0.16±0.03ef
    罗布麻蜜 332.50±53.77fghi 2.02±0.41cdefg 1.64±0.19c
    米团蜜 1346.09±108.60a 9.07±1.36a 4.66±0.35a
    木通蜜 263.84±21.02ghi 5.06±0.68b 0.23±0.04ef
    枇杷蜜 152.58±48.86hi 0.46±0.19g 0.18±0.04ef
    苹果蜜 340.77±50.61fghi 1.92±0.16cdefg 0.55±0.06def
    蒲公英蜜 242.99±36.30ghi 1.00±0.21fg 0.31±0.05ef
    沙枣蜜 256.78±40.65ghi 1.19±0.34efg 0.37±0.09def
    苕子蜜 147.26±47.40i 0.63±0.44g 0.19±0.04ef
    石榴蜜 234.48±43.94ghi 0.72±0.28fg 0.23±0.03ef
    五倍子蜜 164.90±20.37hi 0.82±0.28fg 0.30±0.04ef
    夏枯草蜜 519.92±49.41defg 3.55±0.26bc 0.75±0.07def
    玄参蜜 294.20±29.87ghi 1.59±0.41cdefg 0.48±0.10def
    薰衣草蜜 347.18±82.62fghi 0.58±0.44g 0.12±0.02f
    野桂花蜜 252.93±3.70ghi 1.45±0.36defg 0.36±0.06def
    野黄柏蜜 255.80±30.11ghi 1.14±0.18efg 0.31±0.03ef
    益母草蜜 538.64±45.45defg 2.68±0.44cdef 0.88±0.05de
    益智花蜜 457.65±40.73defgh 1.87±0.34cdefg 0.65±0.08def
    同列数据后不同小写字母表示在0.01水平差异显著。表5同。
    Data with different lowercase letters on same column indicate significant difference at 0.01 level. Same for Table 5.
    下载: 导出CSV

    表  4  抗氧化指标的相关性分析

    Table  4.   Correlation between antioxidant indexes

    指标
    Index
    总酚含量
    Total phenolic content
    FRAP总
    抗氧化能力
    Total antioxidant capacity
    DPPH自由基
    清除能力
    DPPH radical scavenging
    capacity
    总酚含量
    Total phenolic content
    1.000 0.695** 0.801**
    FRAP总抗氧化能力
    Total antioxidant capacity
    0.695** 1.000 0.712**
    DPPH自由基清除能力
    DPPH radical scavenging capacity
    0.801** 0.712** 1.000
    **表示在0.01级别(双尾)相关性显著。表6同。
    ** indicates significance at 0.01 level (two-tailed). Same for Table 6.
    下载: 导出CSV

    表  5  蜂蜜样品对微生物的抑菌圈直径(琼脂扩散法)

    Table  5.   Microbial inhibition zone of honeys (diameters on agar diffusion medium)

    样品名称
    Sample name
    抑菌圈直径
    Inhibition zone/mm
    金黄色葡萄球菌
    S. aureus
    大肠杆菌
    E. coli
    阳性对照(10%苯酚) 30.30±1.07a 29.99±0.62a
    阴性对照(蒸馏水)
    柽柳蜜 14.74±0.98fg nd
    枸杞蜜 11.35±0.43b
    黄芪蜜 24.33±1.21bc
    黄芩蜜 20.04±0.59de
    茴香蜜 25.51±1.04b 12.82±0.48b
    火炭母蜜 14.47±1.36fg
    藿香蜜 23.74±1.06bcd 12.83±0.97b
    九龙藤蜜 12.89±0.44g
    罗布麻蜜 13.66±1.73ef
    苹果蜜 21.06±1.18cde 10.51±0.70b
    蒲公英蜜 15.07±1.16fg
    沙枣蜜 14.44±1.27fg
    苕子蜜 19.32±1.13e
    石榴蜜 17.47±2.02ef
    五倍子蜜 14.72±1.11fg
    薰衣草蜜 13.14±1.16g
    野桂花蜜 13.53±0.37fg
    野黄柏蜜 13.44±0.59fg
    益母草蜜 24.69±0.4bc
    益智花蜜 12.82±1.36g
    “—”表示未检出>8 mm的抑菌圈。
    "—" indicates absence of inhibition zone larger than 8 mm in diameter.
    下载: 导出CSV

    表  6  抗菌活性与抗氧化活性之间的相关性

    Table  6.   Correlation between antibacterial and antioxidative activities of honey

    指标
    Index
    对金黄色葡萄球菌
    抗菌能力
    Antibacterial
    activity against
    S. aureus
    对大肠杆菌
    抗菌能力
    Antibacterial
    activity against
    E. coli
    总酚含量
    Total phenolic content
    −0.089 0.213
    FRAP总抗氧化能力
    Total antioxidant capacity
    −0.306 0.023
    DPPH自由基清除能力
    DPPH radical scavenging capacity
    −0.212 −0.023
    对金黄色葡萄球菌的抗菌能力
    Antibacterial activity against S. sureus
    1 0.321
    对大肠杆菌的抗菌能力
    Antibacterial activity against E. coil
    0.321 1
    下载: 导出CSV

    表  7  蜂蜜样品对金黄色葡萄球菌和大肠杆菌的MIC和MBC

    Table  7.   MIC and MBC ranges of honeys against S. aureus and E. coli

    样品名称
    Sample
    name
    金黄色葡萄球菌
    S. aureus
    大肠杆菌
    E. coli
    最小抑菌浓度
    MIC/%
    最小杀菌浓度
    MBC/%
    最小抑菌浓度
    MIC/%
    最小杀菌浓度
    MBC/%
    枸杞蜜 6.25~10.00 6.25~10.00
    茴香蜜 1.25~2.50 1.25~2.50 6.25~10.00 10.00~12.50
    益母草蜜 1.25~2.50 2.50~3.13
    藿香蜜 3.13~5.00 2.50~3.13 6.25~10.00 10.00~12.50
    苹果蜜 3.13~5.00 3.13~5.00 10.00~12.50 12.50~20.00
    黄芪蜜 3.13~5.00 3.13~5.00
    柽柳蜜 3.13~5.00 3.13~5.00
    苕子蜜 5.00~6.25 5.00~6.25
    黄芩蜜 6.25~10.00 6.25~10.00
    石榴蜜 6.25~10.00 6.25~10.00
    沙枣蜜 6.25~10.00 6.25~10.00
    蒲公英蜜 6.25~10.00 10.00~12.50
    罗布麻蜜 6.25~10.00 12.50~20.00
    野桂花蜜 6.25~10.00 12.50~20.00
    野黄柏蜜 6.25~10.00 12.50~20.00
    五倍子蜜 10.00~12.50 12.50~20.00
    薰衣草蜜 12.50~20.00 12.50~20.00
    火炭母蜜 12.50~20.00 20.00~25.00
    九龙藤蜜 12.50~20.00 25.00~50.00
    益智花蜜 12.50~20.00 25.00~50.00
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出版历程
  • 收稿日期:  2024-02-21
  • 修回日期:  2024-05-11
  • 网络出版日期:  2024-09-19
  • 刊出日期:  2024-07-28

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