Effect of Porcine Antibacterial Peptide against Avian Pathogenic Bacteria

  Objective  Activity of porcine antibacterial peptides (PAP) against avian Salmonella and Escherichia coli was determined for drug development.

  Method  Inhibitive activity of PAP on avian pathogens was studied in vitro on an liquid medium and by an in vivo test.

  Results  PAP at a concentration of 1.0 mg·mL^-1 showed a higher bacteriostatic effect on the solution contaning 10⁶ CFU·mL^-1 of the pathogens than at 0.5, 0.2 or 0.1 mg·mL^-1. Compared with 15 antibiotics, such as amoxicillin, erythromycin, tetracycline, etc., PAP induced the largest inhibition zone on the growth of avian Salmonella FJS13 and E. coli FJE61. In a challenging test on chicken, the PAP administration improved the survival rate of the subcutaneous injected birds.

  Conclusion  PAP could be used as a bioagent to combat the infection on chickens by avian Salmonella and E. coli.