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玉屏风煎剂对德化黑鸡生长性能、免疫调节、血清生化指标的影响

林雪玲 胡美华 林祚贵 徐磊 刘志军 马玉芳

林雪玲,胡美华,林祚贵,等. 玉屏风煎剂对德化黑鸡生长性能、免疫调节、血清生化指标的影响 [J]. 福建农业学报,2024,39(4):369−377 doi: 10.19303/j.issn.1008-0384.2024.04.001
引用本文: 林雪玲,胡美华,林祚贵,等. 玉屏风煎剂对德化黑鸡生长性能、免疫调节、血清生化指标的影响 [J]. 福建农业学报,2024,39(4):369−377 doi: 10.19303/j.issn.1008-0384.2024.04.001
LIN X L, HU M H, LIN Z G, et al. Effects of Yupingfeng Decoction on Growth Performance, Immune Function and Serum Biochemical Indices on Dehua Black Chicken [J]. Fujian Journal of Agricultural Sciences,2024,39(4):369−377 doi: 10.19303/j.issn.1008-0384.2024.04.001
Citation: LIN X L, HU M H, LIN Z G, et al. Effects of Yupingfeng Decoction on Growth Performance, Immune Function and Serum Biochemical Indices on Dehua Black Chicken [J]. Fujian Journal of Agricultural Sciences,2024,39(4):369−377 doi: 10.19303/j.issn.1008-0384.2024.04.001

玉屏风煎剂对德化黑鸡生长性能、免疫调节、血清生化指标的影响

doi: 10.19303/j.issn.1008-0384.2024.04.001
基金项目: 福建省科技计划项目(2019N0025);福建省教育科学“十四五”规划项目(FJJKGZ21-055)
详细信息
    作者简介:

    林雪玲(1974 —),女,硕士,副教授,主要从事兽医中药与动物保健研究,E-mail:linxueling0909@126.com

    通讯作者:

    马玉芳(1970 —),女,博士,教授,主要从事天然产物开放与综合利用研究,E-mail:myfau850@sohu.com

  • 中图分类号: S831

Effects of Yupingfeng Decoction on Growth Performance, Immune Function and Serum Biochemical Indices on Dehua Black Chicken

  • 摘要:   目的  探讨玉屏风煎剂对德化黑鸡生长性能、免疫调节、血清生化指标的影响,并对其安全性进行观察。  方法  黄芪、白术、防风按质量比2:2:1混合煎制,浓缩成含生药1 g·mL−1的玉屏风煎剂。将30日龄体重相近的德化黑鸡160头随机分为低剂量组(1.25 mL·头−1·天−1)、中剂量组(1.875 mL·头−1·天−1)、高剂量组(2.5 mL·头−1·天−1)和空白对照组(0 mL·头−1·天−1),每组4个重复,每个重复10头,煎制玉屏风饮水给药,饲喂试验为期25 d;试验第25 d采血及十二指肠,检测生长性能、十二指肠形态结构、免疫功能、抗氧化能力、血清生化等相关指标。  结果  与对照组相比,1)中、高剂量组日增重分别提高16.77%(P<0.05 )、27.58%(P<0.01 ),3个剂量组饲料转化率分别提高8.30%、14.61%、21.92%;2)3个剂量组血清IL-2含量,中、高剂量组十二指肠黏膜SIgA水平显著提高(P<0.05或P<0.01);3个剂量组血清 IFN-γ、TNF-α含量显著降低(P<0.05或P<0.01)。3)3个剂量组MDA浓度极显著降低(P<0.01),GSH-Px、SOD活性极显著升高(P<0.01),高剂量组T-AOC、CAT活性显著升高(P<0.05或P<0.01)。4)中、高剂量组隐窝深度显著降低(P<0.05),绒隐比显著增加(P<0.05或P<0.01);5)3个剂量组总胆红素浓度、甘油三酯浓度、总胆固醇浓度、谷草转氨酶活性、谷丙转氨酶活性、碱性磷酸酶活性、肌酐浓度、肌酸激酶活性差异均不显著(P>0.05)。  结论  玉屏风煎剂可以提高德化黑鸡的生长性能,改善肠道形态结构,强化抗氧化能力,增强免疫功能,具有抗炎、维持免疫平稳态的作用,使用安全,最适剂量为2.5 mL·头−1·天−1
  • 图  1  玉屏风煎剂对德化黑鸡十二指肠形态结构的影响

    红色箭头:十二指肠绒毛;黄色箭头:隐窝。CK:对照组;L:低剂量组;M:中剂量组;H:高剂量组。

    Figure  1.  Effect of Yupingfeng decoction on duodenal morphology of Dehua black chicken

    Red arrow: duodenal villus; yellow arrow: crypt. CK: control group; L:low-dose group; M:medium-dose group; H: high-dose group.

    表  1  试验鸡分组与处理

    Table  1.   Treatment of the tested chicken

    组别
    Group
    动物数
    Samples number
    玉屏风剂量
    Yupingfeng dosage/(mL·头−1·天−1)
    处理
    Treatment
    对照组Control group 40 0 只饲喂基础日粮,自由饮水
    低剂量组Low-dose group 40 1.250 50 mL中药+1000 mL水,早晚分两次给药,其他时间自由饮水,连用25 d
    中剂量组Medium-dose group 40 1.875 75 mL中药+1000 mL水,早晚分两次给药,其他时间自由饮水,连用25 d
    高剂量组High-dose group 40 2.500 100 mL中药+1000 mL水,早晚分两次给药,其他时间自由饮水,连用25 d
    下载: 导出CSV

    表  2  试验鸡免疫程序

    Table  2.   Immunization program of the tested chicken

    日龄
    Age
    疫苗
    Vaccines
    接种方法
    Vaccination method
    1 d 马立克氏疫苗 颈部皮下注射
    5 d 鸡新城疫L系和传支H120二联疫苗 滴鼻
    7 d 法氏囊疫苗 滴嘴
    10 d 鸡痘疫苗 刺种
    15 d 鸡新城疫、传染性支气管(H52)二联疫苗 滴鼻
    20 d 法氏囊疫苗(二免) 滴嘴
    28 d (H5+H7)三价灭活疫苗 肌注
    35 d (H5+H7)三价灭活疫苗(二免) 肌注
    43 d 鸡新城疫(LaSota株)、传染性支气管炎(M41株)、禽流感(H9亚型,HL株)三联灭活疫苗
    禽流感(H9亚型,HL株)三联灭活疫苗
    肌注
    160 d (H5+H7)三价灭活疫苗(三免) 肌注
    165 d 新支流减四联疫苗 肌注
    下载: 导出CSV

    表  3  玉屏方煎剂对德化黑鸡生长性能的影响

    Table  3.   Effect of Yupingfeng decoction on growth performance of Dehua black chicken

    组别
    Group
    始重
    Initial weight/g
    末重
    Final weight/g
    日增重
    Daily weight gain/(g·d−1)
    日均采食量
    Daily average food intake/(g·d−1)
    料重比
    F/G
    对照组 Control group 353.80±41.04 658.60±69.82Bb 12.40±1.90Bb 37.29±7.22 3.01
    低剂量组 Low-dose group 339.80±41.41 676.40±84.91ABb 13.50±2.08ABb 37.29±7.22 2.76
    中剂量组 Medium-dose group 365.50±45.48 718.60±48.65ABa 14.48±1.54ABa 37.29±7.22 2.57
    高剂量组 High-dose group 348.80±50.23 721.40±72.63Aa 15.82±2.95Aa 37.29±7.22 2.35
    同列数据后不同大写字母者表示差异极显著(P<0.01),不同小写字母者表示差异显著(P<0.05),相同或无字母者表示差异不显著(P>0.05);下表同。
    In the same column, values with different uppercase letters mean very significant difference (P<0.01), with different small letters, significant difference (P<0.05), and with the same or no letter, no significant difference (P>0.05); Same for below.
    下载: 导出CSV

    表  4  玉屏风煎剂对德化黑鸡血清细胞因子及肠道SIgA抗体的影响

    Table  4.   Effect of Yupingfeng decoction on cytokines and SIgA content of Dehua black chicken

    组别 Group IL-2/(pg·mL−1) IL-6/(pg·mL−1) IFN-γ/(pg·mL−1) TNF-α/(pg·mL−1) SIgA/(μg·mL−1)
    对照组 Control group 154.10±17.33Bb 19.71±2.57 62.64±5.67Aa 48.93±2.97Aa 1221.00±45.75Bb
    低剂量组 Low-dose group 181.00±11.27Aa 19.10±1.93 51.15±4.24Bb 42.54±3.75ABb 1342.0±40.87ABab
    中剂量组 Medium-dose group 182.30±15.97Aa 19.34±2.53 47.89±4.90Bb 42.39±4.89ABb 1408.0±136.40ABa
    高剂量组 High-dose group 190.00±24.36Aa 18.25±1.93 49.96±5.03Bb 41.21±5.18Bb 1471.00±201.10Aa
    下载: 导出CSV

    表  5  玉屏风对德化黑鸡抗氧化功能的影响

    Table  5.   Effect of Yupingfeng decoction on antioxidant indices of Dehua black chicken

    组别
    Group
    丙二醛
    MDA/(nmol·mL−1)
    谷胱甘肽过氧化物酶
    GSH-Px/(U·mL−1)
    超氧化物歧化酶
    SOD/(U·mL−1)
    总抗氧化能力
    T-AOC/(U·mL−1)
    过氧化氢酶
    CAT/(U·mL−1)
    对照组 Control group 7.06±0.24Aa 224.60±12.93Cc 46.61±6.57Cc 19.72±2.63Bb 162.60±19.00ABb
    低剂量组 Low-dose group 5.77±0.44Bb 320.00±17.17Bb 57.94±5.90Bb 20.5±2.21ABab 151.50±20.49Bb
    中剂量组 Medium-dose group 5.71±0.44Bb 332.00±15.03Bb 65.70±7.95Bb 21.7±1.48ABab 177.30±20.24ABab
    高剂量组 High-dose group 5.06±1.01Bb 403.70±29.08Aa 82.08±9.20Aa 24.12±2.70Aa 196.50±25.96Aa
    下载: 导出CSV

    表  6  玉屏风煎剂对德化黑鸡十二指肠形态结构的影响

    Table  6.   Effect of Yupingfeng decoctions on duodenal morphology of Dehua black chicken

    组别
    Group
    绒毛高度
    Villus height/mm
    隐窝深度
    Crypt depth/mm
    绒隐比
    V/C
    对照组 Control group 1.21±0.17 0.253±0.024ABa 4.75±0.43Bb
    低剂量组 Low-dose group 1.28±0.17 0.263±0.015Aa 4.87±0.52Bb
    中剂量组 Medium-dose group 1.29±0.13 0.219±0.026Bb 6.00±1.13ABa
    高剂量组 High-dose group 1.37±0.08 0.222±0.017Bb 6.18±0.33Aa
    下载: 导出CSV

    表  7  玉屏风煎剂对德化黑鸡生化指标的影响

    Table  7.   Effect of Yupingfeng decoction on serum biochemical indices of Dehua black chicken

    组别
    Group
    甘油三脂
    TG/(mmol·L−1)
    总胆固醇
    CHOL/ (mmol·L−1)
    肌酸激酶
    CK/(U·L−1)
    肌酐浓度
    CREA/(μmol·L−1)
    谷丙转氨酶
    ALT/(U·L−1)
    谷草转氨酶
    AST/(U·L−1)
    碱性磷酸酶
    ALP/(U·L−1)
    总胆红素
    TBIL/(μmol·L−1)
    对照组
    Control group
    0.71±0.25 2.73±0.33 2025.00±528.50 18.50±5.68 6.20±2.10 181.70±19.40 4967.00±2014.00 3.31±1.55
    低剂量组
    Low-dose group
    0.58±0.08 2.91±0.39 2006.00±440.60 15.00±3.57 5.38±2.20 191.40±14.38 6017.00±1418.00 3.64 ±0.91
    中剂量组
    Medium-dose group
    0.75±0.12 2.93±0.33 2150.00±531.90 17.50±4.21 7.38±2.39 201.30±24.12 4674.00±2671.00 3.31 ±1.34
    高剂量组
    High-dose group
    0.69±0.20 2.72±0.42 2380.00±590.50 22.36±9.57 6.30±2.21 179.60±18.99 5155.00±2166.00 4.21 ±1.59
    下载: 导出CSV
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  • 收稿日期:  2024-03-17
  • 修回日期:  2024-04-05
  • 网络出版日期:  2024-06-26
  • 刊出日期:  2024-04-28

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